Gallbladder adenocarcinoma (GBC) is a rare and challenging diagnosis, often associated with chronic gallstones and discovered incidentally during histopathological examination. It may present in early or late stages without overt clinical or radiological signs. Laparoscopic cholecystectomy is commonly performed for gallstones, and in such cases, gallbladder cancer may be detected even in the absence of a visible mass or atypical clinical presentation. A 68-year-old female with no significant medical history presented with a gallstone, confirmed via abdominal ultrasound, showing multiple stones and sludge. The patient underwent an elective laparoscopic cholecystectomy without intraoperative complications, such as bile spillage, significant bleeding, or organ injury. Postoperative recovery was uneventful, with no additional symptoms. Histopathological analysis revealed grade 2 (moderately differentiated) adenocarcinoma extending to the hepatic surface of the gallbladder. Gallbladder adenocarcinoma can present silently in its early stages, underscoring the importance of histopathological examination of all cholecystectomy specimens, especially in older patients with gallstones. Avoidance of bile spillage during surgery is crucial for improving prognosis. Further metastatic evaluation through chest, abdominal, and pelvic CT shows no abnormalities in this case. Regular follow-up with hepatobiliary and oncology teams was recommended.
