2022, Volume 15, Issue 11, pp 1330 – 1333

Relevant biomarkers of kidney allograft rejection

SCImago Journal & Country Rank

Issues

Special Issues

Authors and Affiliations

Corresponding Author: Ion Mărunțelu, Immunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Centre of Immunogenetics and Virology, Fundeni Clinical Institute, Bucharest, Romania. E-mail: ion.maruntelu@drd.umfcd.ro

Abstract

This review focuses on the new relevant biomarkers proposed for the diagnosis of different types of allograft rejections. The immune response against the transplanted tissues can lead to rejection. Kidney allograft rejection occurs when the recipient component’s immune system reacts against the donor’s cells. MicroRNAs, dd-cf DNA, CD103 markers, CXCR3 chemokine receptor, IP-10, KIR genes, HLA antibodies, the perforin and granzyme B molecules – the constant assessment of all these parameters could prevent acute rejection episodes and kidney injuries. In this way, both immune response and tissue destruction biomarkers are essential for the long-term survival of kidney-transplanted patients. They also contribute to personalizing treatments, precisely personalized immunosuppressive regiments.

Keywords

About this article

PMC ID: 9762359
PubMed ID: 36567832
DOI: 10.25122/jml-2022-0181

Article Publishing Date (print): 11 2022
Available Online: 

Journal information

ISSN Printing: 1844-122X
ISSN Online: 1844-3117
Journal Title: Journal of Medicine and Life

Copyright License: Open Access

This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.


SCImago Journal & Country Rank

Issues

Special Issues