Prevalence of Methylenetetrahydrofolate Reductase C677T Polymorphism in women with Polycystic Ovary Syndrome in southeast of Iran • JML Journal of Medicine and Life

2015, Volume 8, Issue Spec Iss 3, pp 229 – 232

Prevalence of Methylenetetrahydrofolate Reductase C677T Polymorphism in women with Polycystic Ovary Syndrome in southeast of Iran

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Authors and Affiliations

Naghavi A ^*

Mozdarani H ^*

Garshasbi M ^*

Yaghmaei M ^**

* *Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran,

** **Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Shahid Beheshti University, Tehran, Iran

Correspondence to: Dr. Hossein Mozdarani, PhD, Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, P.O. BOX.14115-331, Tehran, Iran, Tehran, Chamran Highway Jalal-eHighway, Al-e-Ahmad, Iran, Phone: +982182883831, +989121374831, Fax: +982188006544, E-mail: mozdarah@modares.ac.ir

Abstract

Background: One of the notable enzymes in the metabolism of folate is Methylenetetrahydrofolate reductase enzyme, this enzyme is necessary for some biological mechanisms. Mutations in the MTHFR gene could reduce the enzyme activity.

Aim: The objective of this research was to assess the prevalence of the very general polymorphism, C677T, in females with polycystic ovary syndrome in the southeastern of Iran.

Methods: This research was a case–control research and was conducted on 112 PCOS women and 196 healthy controls. Single type nucleotide polymorphisms (SNP) were genotyped by employing the polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP).

Results: It noticed that in C677T, the pervasiveness of C/ C, C/ T, and T/ T genotypes was 54.5%, 34%, and 11.5%, respectively. The repetition of TT genotype was notably higher in PCOS women contrasted to controls.

Conclusions: the appearance of 677T allele could be a danger agent for PCOS susceptibility in the southeast of Iran.

Keywords

Methylenetetrahydrofolate reductaseC677T polymorphismPolycystic Ovary Syndrome

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About this article

PMC ID: 5348926
PubMed ID: 28316696
DOI:

Article Publishing Date (print): 2015
Available Online:

Journal information

ISSN Printing: 1844-122X
ISSN Online: 1844-3117
Journal Title: Journal of Medicine and Life

Copyright License: Open Access

This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.