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Category: Issue 12

In silico study, synthesis, and antineoplastic evaluation of thiazole-based sulfonamide derivatives and their silver complexes with expected carbonic anhydrase inhibitory activity

Naji Esraa Mahdi 1 et al.
2023
Issue 12
pp 1857 - 1863
DOI: 10.25122/jml-2023-0180

This study aimed to design, synthesize, and evaluate the cytotoxic activity of novel thiazole-sulfanilamide derivatives, specifically compounds M3, M4, and M5, through molecular docking and biological assays. The synthesis...

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Add-on treatment with Cerebrolysin improves clinical symptoms in patients with ALS: results from a prospective, single-center, placebo-controlled, randomized, double-blind, phase II study

Firstenfeld Alfredo José 1 et al.
2023
Issue 12
pp 1750 - 1755
DOI: 10.25122/jml-2023-0459

Amyotrophic lateral sclerosis (ALS) is a devastating and progressive neurodegenerative disease with limited treatment options available. Cerebrolysin is a drug candidate for the treatment of ALS because of its neuroprotective...

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Clinical and radiological outcomes of open reduction alone versus open reduction with pelvic osteotomy for developmental dysplasia of the hip in children over 1.5 years of age

Aljanabi Ali Saleh 1 et al.
2023
Issue 12
pp 1839 - 1843
DOI: 10.25122/jml-2023-0212

Developmental dysplasia of the hip (DDH) is commonly addressed through surgical intervention, usually performed in a specialized tertiary care facility. The purpose of this study was to evaluate the surgical outcomes in patients...

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