A review of the literature and current practice shows that Romania lacks both a National Electronic Register for Cardiovascular Diseases (NERCVD) and a dedicated National Electronic Register for Cardiovascular Rehabilitation (NERCVR). Such registers are increasingly essential in the digital era, particularly within the European Union, where several member states (e.g., Sweden, Germany, the Netherlands) already operate national cardiovascular registries. To identify a feasible IT architecture for a Romanian registry, we assessed available platforms and selected the Research Electronic Data Capture (REDCap) web platform as the most suitable, based on its functionality, infrastructure requirements, and flexibility. Using REDCap, we designed the project “Cardiovascular Rehabilitation and Secondary Prevention” and configured a proof-of-concept NERCVR. We managed to configure, taking into account previous experiences in the field presented in the discussions, a demonstrative model – proof of concept type – of the National Electronic Register for Cardiovascular Rehabilitation, with other types of data categories and related digital components to be created in the future, thus concluding the final form of a National Electronic Register for Cardiovascular Diseases.