The rising prevalence of obesity and diabetes underscores the need for innovative approaches to promote healthier lifestyles and improve clinical outcomes. Emerging evidence suggests that integrating mobile health (mHealth) technologies, such as smartphone applications and wearable devices, may provide a promising solution. mHealth interventions have the potential to enhance the delivery and accessibility of nutritional therapy and lifestyle modification programs for people with obesity and diabetes. This systematic review examines the available literature on the application and effectiveness of mHealth-based tools and technologies in managing these chronic conditions, offering insights into the current state of the field and opportunities for future research and clinical implementation. The review explores the diverse range of mHealth apps and devices utilized, their impact on weight loss, glycemic control, and other health-related outcomes, and the challenges and limitations associated with their use. This study highlights future directions and the growing importance of mHealth in the comprehensive management of obesity and diabetes to inform healthcare professionals, researchers, and policymakers about the potential of these innovative approaches to enhance patient care and improve population health.