Amelogenesis imperfecta refers to a group of hereditary diseases that affect dental enamel, often leading to a wide range of clinical manifestations and aesthetic concerns. This case report describes a female patient diagnosed with amelogenesis imperfecta associated with a skeletal open bite. The treatment approach was multidisciplinary. Periodontal therapy was initiated, followed by orthodontic treatment using brackets on temporary crowns to expand and coordinate the maxillary and mandibular arches. Subsequently, orthognathic surgery, including a LeFort I osteotomy and genioplasty, was performed. The fixed prosthodontic rehabilitation performed with metal-ceramic crowns was the last step of the treatment. The final result was both functionally and esthetically satisfactory for the patient.