The current study aimed to assess the immediate and localized effect of Kinesio Taping (KT) on hand grip strength. A cross-sectional study was conducted on 60 sedentary female university students (aged 18-23) divided into two groups of 30 subjects each. The experimental group received KT with 50% tension of the tape on the forearm and 100% tension on the hand, and the control group received a placebo application of KT (KT without tension on the hand and forearm). Hand grip strength was assessed before and immediately after applying KT using a hand-held dynamometer with a one-minute rest between trials. The experimental group detected a significant improvement in hand grip strength during the post-intervention stage compared to the control group (mean difference 9.72 Lbs; 95% CI, -12.90 to -6.54; P<0.05) with a medium effect size. In addition, a significant improvement in handgrip strength was observed between pre-intervention and post-intervention in the experimental group (mean difference 6.5 Lbs.; 95% CI, -7.58 to -5.42; P<0.05) with a high effect size. However, the control group failed to show significant improvement in handgrip strength between pre-and post-intervention (P=0.666). KT application on the hand and forearm immediately augmented the hand grip strength of the dominant hand in sedentary female university students.