Coronavirus is a life-threatening disease with many devastating psychological, emotional, social, and sexual implications, especially for vulnerable people. This cross-sectional study aimed to assess adolescent health and anxiety during the COVID-19 pandemic. 1300 male adolescents filled out the Male Adolescent Health Need Assessment Scale (MAHNAS) and corona-related anxiety scale (CRAS) from January to May 2021. Data analysis was done using SPSS version 22. The mean age of adolescents was 15.5±2.25, and most of them (65%) were studying in high school. The mean scores for physical health were 78±7.55, psychological health 48.8±5.55, social health 48.21±8.61, sexual health 50.35±9.05, and anxiety scores were severe (46.76) in this study. There was a significant negative relationship between anxiety and health needs. The COVID-19 pandemic greatly affected the health needs of adolescents. Effective approaches and policies in this crisis, especially for adolescents, can alleviate the anxious reactions and be a way to meet their health needs appropriately.