Implant-prosthetic rehabilitation registers multiple variants, but their short- and long-term evolution has been a frequent concern. This study aimed to evaluate the peri-implant bone resorption at the level of the tilted implants in the SKY fast & fixed restorations, with reference to clinical and treatment parameters. An observational study was conducted on a convenience sample of patients with implant-prosthetic rehabilitation in one or both jaws, according to the SKY fast & fixed protocol (Bredent, Germany). Bone resorption was assessed on panoramic radiography. Other data were collected from the patient’s medical records. Thirty tilted implants were analyzed, 12 of which were in the maxilla and 18 in the mandible. After the follow-up period, both bone resorption (maximum 7 mm) and bone apposition (maximum 8 mm) were observed. There was a tendency for the resorption to be more pronounced in the mandible, in patients where tooth loss was due to periodontal disease, and when implants with length less than 16 mm were used. Resorption was statistically significantly lower when bone addition materials and membranes were used at the extraction socket, and when SKY fast & fixed rehabilitation was performed in both jaws. SKY fast & fixed implant-prosthetic technique, which involves applying a small number of implants, and a fixed prosthesis corresponding to a shortened dental arch, is a viable method of treatment that outcomes the need for complex and expensive surgical interventions, and proves to be beneficial in maintaining the optimal parameters of bone support.