Organ failure can be defined as a relevant concept of functional-anatomical condition of body structural change. Anatomical, functional disorders of the body are the expression of structural remodeling. The process is complex, including the first functional cell mass reduction (in particular, apoptosis and necrosis), and on the other hand the development of fibrosis process with a starting point at the extracellular matrix. Both mechanisms that take place are caused by etiological factors, enhanced, favoring the developer cytokines mediated by inflammatory processes such as premature death and functional constituent cells of the body; secondly the inflammation leads to fibrosis. The article review is a summary of the knowledge that exist at the level of the anatomical organ remodeling.