Cyprus has been affected by COVID-19 since March 2019. With a case fatality rate of 2.6% (until June 2020) and the social isolation measures enforced on the population, the population’s mental health has been affected. We aimed to assess the mental health burden of the Cypriot population during the outbreak and to explore the potential influence factors.

Using a web-based cross-sectional survey, we collected data from 216 volunteers regarding demographic data, COVID-19-related knowledge, generalized anxiety disorder (GAD), and major depressive symptoms. The overall prevalence of GAD and major depressive symptoms of the public were 13.89% and 8.33%, respectively. No demographic had shown any statistical significance with GAD. The younger age group of the study showed a statistically significant association with major depressive symptoms when compared to the adult population in both univariate and multivariable analyses.

Our study identified a mental health burden of the Cypriot population, especially the younger age groups. As part of the preparedness for situations as the one we are experiencing and the future impact the pandemic may have on society, interventions should be focused on vulnerable groups of the population to alleviate the psychosocial effects.