Introduction: One of the main parts of the lives of infertile impaired is social relationships and their family functions. This study aimed to compare the family function based on the McMaster model in fertile and infertile women.

Materials and Methods: This research is a similar one. The population consisted of all infertile women referred to the two infertility centers and fertile females related to health areas located in the same area in Tehran. The sampling method was the convenience one and in both groups, 50 women were recruited as samples and they responded to the demographic and Family Assessment Device (FAD) questionnaires. The obtained information was investigated by using inferential and descriptive statistics and SPSS 22 software.

Findings: The results showed the following behavioral control variables (p = 0/ 003), roles (p = 0/ 002), emotional responsiveness (p = 0/ 020) and emotional involvement (p = 0/ 006). There was a clear distinction between fertile and infertile women and infertile women obtained worse scores.

Conclusion: The results indicated that infertile women have crucial problems in family functioning that can have an impact on other aspects of life and their health.