2010, Volume 3, Issue 4, pp 416 – 420

Serum levels of adipokines resistin and leptin in patients with colon cancer


Special Issues

Authors and Affiliations

Correspondence to:Aurora Salageanu, M.D, Ph.D, Infection and Immunity Laboratory, National Institute for Research and Development in Microbiology and Immunology ‘Cantacuzino’, 103 Spl. Independentei, District 5, 050096 Bucharest, Romania , e-mail immuno@cantacuzino.ro


Adipose tissue displays characteristics of an endocrine organ releasing a number of adipocyte–specific factors known as adipocytokines.It has been recently suggested that adipocytokines may play a role in pathogenesis and progression of certain cancers, in particular in colorectal cancer. The aim of this study was to investigate the association between several blood adipocytokine levels and clinicopathological characteristics of colon cancer patients undergoing surgery. The study group comprised of 29 patients who underwent surgical resection for colon cancer at Emergency University Hospital Bucharest and 27 healthy volunteers. The serum levels of adipocytokines were measured using multianalyte xMap profiling technology (Luminex). Resistin levels were significantly higher in colon cancer patients while leptin serum levels were significantly lower as compared to controls. Leptin levels decreased gradually with tumor stage and aggressiveness. Taken together, these results of this study suggest that adipokines, in particular resistin and leptin may be involved in development and progression of colon cancer.


About this article

PMC ID: 3019064
PubMed ID: 21254741

Article Publishing Date (print): 15-11-2010
Available Online: 25-11-2010

Journal information

ISSN Printing: 1844-122X
ISSN Online: 1844-3117
Journal Title: Journal of Medicine and Life

Copyright: © 2020 Carol Davila University Press. Romania

Copyright License: Open Access

This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.