2015, Volume 8, Issue Spec Iss 3, pp 72 – 76

A study of the influence of dexamethasone on lipid profile and enzyme lactate dehydrogenase

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Authors and Affiliations

Correspondence to: M Mahboubi, Ph.D. Abadan School of Medical Sciences, Abadan, Iran, Abadan, Iran, Phone: +989126809526, E-mail: mm59m@yahoo.com.

Abstract

Dexamethasone is an exceptionally applied glucocorticoid unfortunately prescribed too much. This drug is attached to its receptors in the cytoplasm by going through the cell layer, and opens the cell nucleus by the drug-receptor system, being ultimately responsible for systematic effects of corticosteroids. This study was conducted to explore the influence of dexamethasone on serum level of some biochemical parameters in adult men rats.

40 adult male rats were put into 4 test and check collections. The test collection only received saline and the experimental group received dexamethasone of 0.4, 0.7, and 1 mg/ kg doses daily in the form of intraperitoneal inoculation of 1 mL/ day. After serum separation, the serum value of cholesterol, triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and lactate dehydrogenase were measured and the outcomes were examined by using SPSS and Dunnett software.

The test of lipid profile and lactate dehydrogenase was done by using the biochemistry tools and the collections were examined. In this research, meaningful differences in the application of the above hormones were not observed up to 0.7 mg/ kg dose. However, important differences were seen in higher doses i.e. 1mg/ kg in the test collection associated with the administration group (P<0.05).

The final result was that the injection of dexamethasone followed in the development of cholesterol and adverse lipid and it could cause tissue damage by increasing lactate dehydrogenase.

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About this article

PMC ID: 5348935
PubMed ID: 28316669
DOI: 

Article Publishing Date (print): 2015
Available Online: 

Journal information

ISSN Printing: 1844-122X
ISSN Online: 1844-3117
Journal Title: Journal of Medicine and Life

Copyright: © 2020 Carol Davila University Press. Romania

Copyright License: Open Access

This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.

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