2011, Volume 4, Issue 3, pp 297 – 301

A special case of acute leukemia in childhood


Special Issues

Authors and Affiliations

Correspondence to:Ion Dorin Bleahu, MD, PhD, ‘Fundeni’ Clinical Institute, Hematology Department, Bucharest, Romania,e-mail dorinbleahu@gmail.com


Hybrid leukemia is a clinical entity that includes: biphenotypic leukemia, characterized by the presence of markers of more than two lineages of a single tumor cell, bilineage leukemia, a combination of more than two lineage markers on two distinct blast cells, and biclonal leukemia, the concomitancy of more than two types of leukemic cells, derived from different clonal expansions. We present a case of a 7–year–old female diagnosed with bilineage leukemia. We propose a treatment for biphenotypic/bilineage leukemia in the cases with good prognostic factors. We suggest that hematopoietic stem cell transplantation is often not required for cure of these patients.


About this article

PMC ID: 3168818
PubMed ID: 22567056

Article Publishing Date (print): 15-08-2011
Available Online: 25-08-2011

Journal information

ISSN Printing: 1844-122X
ISSN Online: 1844-3117
Journal Title: Journal of Medicine and Life

Copyright: © 2020 Carol Davila University Press. Romania

Copyright License: Open Access

This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.