2011, Volume 4, Issue 2, pp 163 – 167

Effects of exogenous antioxidants on oxidative stress in pregnancy


Special Issues

Authors and Affiliations

Correspondence to:Staicu Mihaela–Luminiţa, MD, PhD, ‘Carol Davila’ University of Medicine and Pharmacy, 37 Dionisie Lupu Street, Bucharest, Romania


Objective: The present study evaluated the effects on gestation, in terms of oxidative stress, of two antioxidant factors–vitamin E and coenzyme Q10–during pregnancy, with the purpose of applying the results in further human clinical practice.

Methods: For each aspect we have studied, we used three types of female rats of Wistar race (un–pregnant, primiparous, multiparous), divided in 10 rats/group. From the blood we have sampled, we have determined the oxidative stress (OS) markers: malondialdehyde (MDA) and carbonylated proteins (CP), but also the markers of the antioxidant defense: the hydrogen donor capacity of the plasma (HD) and the sulfhydryl groups (SH).

Results: Vitamin E administration determines significant decreases of MDA and significant increases of CP and HD at primiparous, and also significant increases of SH groups at multiparous. In the case of pregnant animals that received CoQ10 in antioxidant complexes, we have observed an increase of oxidative stress (OS)–MDA in primiparous and CP in multiparous.

Conclusions: In the case of Vitamin E, taking into account the benefits on redox homeostasis, the decrease of OS, the authors recommend vitamin E administration during pregnancy. However, because of the increase of the OS in the case of pregnant animals, the authors do not recommend the administration of CoQ10 in antioxidant complexes during pregnancy.


About this article

PMC ID: 3124270
PubMed ID: 21776299

Article Publishing Date (print): 15-05-2011
Available Online: 25-05-2011

Journal information

ISSN Printing: 1844-122X
ISSN Online: 1844-3117
Journal Title: Journal of Medicine and Life

Copyright: © 2020 Carol Davila University Press. Romania

Copyright License: Open Access

This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.