Colon capsule endoscopy is regarded as an option to complement or even replace diagnostic colonoscopy in selected cases.

Since capsule lacks the capability of taking biopsies, a diagnosis of colon cancer usually requires a further confirmation by colonoscopy.

A series of seven patients who had highly suspicious lesions at capsule endoscopy (five-colon tumors, one gastric tumor and one small bowel tumor) and in whom the clinical decision and treatment was solely based on capsule findings, are presented. The diagnosis of cancer was confirmed in all cases by surgery and histology.

Conclusion: In selected patients with a high index of clinical suspicion of cancer, PillCam colon 2 capsule endoscopy might be a sufficient tool for diagnosis.